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Updated: Jul 19, 2026

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
Functional impairment of CD4 T cells despite normalization of T cell number in HIV
Kenneth S Knox1, Richard B Day, Lisa M Kohli
1Pulmonary Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Abstract:
Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.
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