Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The sodium bicarbonate cotransporter: structure, function, and regulation.

Angelito A Bernardo1, Christian M Bernardo, Doris Joy Espiritu

  • 1Department of Medicine, Section of Nephrology, University of Illinois at Chicago, 820 S. Wood Street, Chicago, IL 60612, USA.

Seminars in Nephrology
|October 31, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanded hemodialysis as effective alternative to on-line hemodiafiltration: A randomized mid-term clinical trial.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·2021
Same author

Medium cut-off dialyzers in a large population of hemodialysis patients in Colombia: COREXH registry.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·2020
Same author

Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease.

Clinical and experimental nephrology·2019
Same author

Intradialytic kinetics of middle molecules during hemodialysis and hemodiafiltration.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2018
Same author

Hypoalbuminemia: a price worth paying for improved dialytic removal of middle-molecular-weight uremic toxins?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2018
Same author

Peptiduria: a potential early predictor of diabetic kidney disease.

Clinical and experimental nephrology·2018

The Na(+)-coupled HCO(3)(-) transporter (NBC) family is vital for maintaining acid-base balance. Mutations in kidney NBC1 cause disorders, prompting structural studies to understand its abnormal activity.

Area of Science:

  • Physiology
  • Molecular Biology
  • Biochemistry

Background:

  • The Na(+)-coupled HCO(3)(-) transporter (NBC) family is crucial for acid-base homeostasis.
  • NBC transporters are expressed in nearly all tissues, with significant roles identified in kidney proximal tubule HCO(3)(-) reabsorption.

Purpose of the Study:

  • To investigate the role of the NBC family in cell pH regulation across various tissues.
  • To understand the mechanism of abnormal NBC1 activity due to mutations, particularly in the kidney.

Main Methods:

  • Literature review of existing studies on NBC family function and mutations.
  • Analysis of structural studies related to NBC1 mutations and their clinical implications.

Main Results:

Related Experiment Videos

  • Ubiquitous expression of NBC family members suggests a widespread role in cellular pH regulation.
  • Mutations in the kidney NBC (NBC1) are linked to significant pathophysiologic conditions and clinical disorders.

    • Conclusions:

    • The NBC family plays an indispensable role in maintaining acid-base balance.
    • Understanding NBC1 structure and function is critical for addressing associated clinical disorders.