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Updated: Jul 19, 2026
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
Investigation of uterine peristalsis diurnal variation
Aki Kido1, Kaori Togashi, Asako Nakai
1Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. akikido@kuhp.kyoto-u.ac.jp
Background:
In women of reproductive age, wavelike movements of the subendometrial myometrium, which is called uterine peristalsis, is considered to be related with fertility and menstrual problems. This is because the direction and frequency of peristalsis is known to be different among menstrual cycle phases. However, nothing is known as regarding diurnal variations. This study was designed to evaluate for the presence of a diurnal variation in uterine peristalsis.
Materials And Methods:
MR studies were performed on 12 volunteers of reproductive age using a 1.5-T magnet, four times per day (at 0800, 1300, 1800 and 2300 h) during three (periovulatory, luteal and menstrual) phases of one menstrual cycle. Sixty images were obtained by half-Fourier acquisition single-shot turbo spin echo every 2 s and displayed on cine mode. Semiautomated software was utilized to discern the presence of peristaltic waves, as well as peristaltic frequency and direction. The presence of sustained contractions was visually determined.
Results:
There was no statistically significant difference during the daytime for frequency and direction of uterine peristalsis for all menstrual cycle phases. Nonetheless, peristaltic frequency and direction fluctuated during each cycle. Statistically significant peristaltic suppression was observed in association with sustained contractions during the periovulatory phase.
Conclusions:
A diurnal variation was not observed for uterine peristalsis. Sporadic changes in peristaltic frequency were observed and appear to be closely related to sustained uterine contractions.
