Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

LINKAGE programs: linkage analysis for monogenic cardiovascular diseases.

Lin Li1, Qing K Wang, Shaoqi Rao

  • 1Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA.

Methods in Molecular Medicine
|October 31, 2006
PubMed
Summary

Identifying human disease genes through linkage analysis offers insights into disease pathogenesis. This method, using the LINKAGE package, aids in positional cloning for monogenic disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo99mTc-HYNIC-annexin V imaging of early tumor apoptosis in mice after single dose irradiation.

Journal of experimental & clinical cancer research : CR·2009
Same author

Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia.

Archives of gynecology and obstetrics·2009
Same author

[Measurement of fine-structure branching ratios for Rb-He optical collisions].

Guang pu xue yu guang pu fen xi = Guang pu·2009
Same author

[The prognostic value of a modified WPSS based on routine laboratory parameters in patients with myelodysplastic syndromes: a preliminary result].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2009
Same author

Lessons learned from the application of a Vietnamese surname list for survey research.

Journal of immigrant and minority health·2009
Same author

Variations of protein levels in human amniotic fluid stem cells CD117/2 over passages 5-25.

Journal of proteome research·2009

Area of Science:

  • Human genetics
  • Molecular biology
  • Bioinformatics

Background:

  • Identifying disease genes is crucial for understanding pathogenesis.
  • Positional cloning relies on determining a gene's chromosomal location.
  • Linkage analysis is a key technique in positional cloning.

Purpose of the Study:

  • To describe model-based human genetic linkage analysis.
  • To demonstrate its application in positional cloning of disease genes.
  • To introduce the LINKAGE computer package for genetic analysis.

Main Methods:

  • Model-based linkage analysis for monogenic disorders.
  • Utilizing the LINKAGE computer package.
  • Analyzing hypothetical pedigrees with known inheritance patterns.

Related Experiment Videos

Main Results:

  • Demonstrated the effectiveness of model-based linkage analysis.
  • Illustrated the application of the LINKAGE package for mapping disease genes.
  • Showcased analysis for autosomal-dominant, autosomal-recessive, and genetic heterogeneity.

Conclusions:

  • Model-based linkage analysis is a powerful tool for positional cloning.
  • The LINKAGE package facilitates genetic analysis of monogenic disorders.
  • This approach aids in identifying molecular determinants of diseases.