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Updated: Jul 19, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
[Relationships between oral allergy syndrome and sensitization to pollen antigen, especially to mugwort]
Kohji Asakura1, Tomo Honma, Nochikazu Yamazaki
1Department of Otorhinolaryngology, Muroran City General Hospital. murohosp012@kujiran.jp
Background:
In order to know the relationships between mugwort pollinosis and oral allergy syndrome (OAS), an etiological study was performed at Muroran City, where mugwort is the most frequent cause of pollinosis.
Methods:
Allergic rhinitis patients positive to serum IgE to birch, mugwort or grass pollen visited to the outpatient-clinic of Otorhinolaryngology of Muroran City General Hospital from 1998 to 2002, were studied by a questionnaire concerning a past-history of OAS.
Results:
The prevalence of OAS was significantly higher in patients positive to serum IgE antibody specific to birch pollen or mugwort pollen than those negative to each pollen-specific antibody (birch; 54.5 vs 23.5%, p<0.0001, mugwort; 41.0 vs 21.5%, p<0.01). The main causative foods were fruits of rose family in patients with only birch pollen-specific IgE antibody, and were those other than rose family, such as kiwi, melon, orange, celery and onion in those with only mugwort pollen-specific IgE antibody. The patients group with high Lumiward score to mugwort pollen tended to include severe OAS cases.
Conclusion:
A close relationship was suggested between mugwort pollen sensitization and OAS.
Insights
Mugwort pollinosis is closely linked to oral allergy syndrome (OAS). Patients allergic to mugwort pollen frequently experience OAS, often with specific food triggers like kiwi and celery.
Area of Science:
- Immunology
- Allergology
- Environmental Health
Context:
- Muroran City experiences high rates of mugwort pollinosis.
- Oral allergy syndrome (OAS) prevalence was investigated in relation to pollen allergies.
- A significant portion of allergic rhinitis patients exhibit OAS.
Purpose:
- To determine the relationship between mugwort pollinosis and oral allergy syndrome (OAS).
- To identify specific food triggers associated with mugwort and birch pollen sensitization.
- To assess the correlation between mugwort pollen-specific IgE levels and OAS severity.
Summary:
- A study of allergic rhinitis patients found a higher prevalence of OAS in those with IgE antibodies to birch or mugwort pollen.
- Patients with mugwort pollen sensitization showed OAS reactions to non-rose family fruits and vegetables.
- Higher mugwort pollen sensitivity scores correlated with more severe OAS cases.
Impact:
- Establishes a significant association between mugwort pollen sensitization and OAS.
- Informs clinical practice regarding the diagnosis and management of OAS in pollen-allergic individuals.
- Highlights the importance of considering OAS in patients with seasonal allergies.
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