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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Neurologic manifestations in children with influenza B virus infection
Chien-Hui Lin1, Yhu-Chering Huang, Cheng-Hsun Chiu
1Division of Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan.
The Pediatric Infectious Disease Journal
|October 31, 2006
Insights
Influenza B virus can cause serious neurologic issues like seizures and encephalitis in hospitalized patients. Prompt antiviral treatment is crucial for preventing long-term complications such as paralysis.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Influenza B virus infections are common causes of respiratory illness.
- Neurologic manifestations associated with influenza are increasingly recognized.
- Understanding the spectrum of neurologic complications is vital for patient management.
Purpose of the Study:
- To investigate the incidence and types of neurologic manifestations in hospitalized patients with influenza B virus infection.
- To evaluate the impact of antiviral therapy on recovery and neurologic sequelae.
Main Methods:
- Retrospective review of 92 hospitalized patients diagnosed with influenza B virus infection over 29 months.
- Analysis of clinical data, including presenting symptoms, neurologic examinations, and treatment outcomes.
Main Results:
- 11 (12%) of 92 patients exhibited neurologic manifestations.
- Febrile seizures occurred in 4 patients; encephalopathy/encephalitis in 7 patients.
- One patient receiving no antiviral therapy developed quadriplegia and developmental delay.
Conclusions:
- Influenza B virus infection can lead to significant neurologic complications in hospitalized patients.
- Antiviral therapy appears critical in preventing severe neurologic sequelae.
- Early diagnosis and treatment are essential for favorable outcomes in influenza B-associated neurologic disease.
Abstract:
During a 29-month period, 11 (12%) of 92 hospitalized patients with influenza B virus infection presented neurologic manifestations, which included febrile seizure in 4 cases and encephalopathy/encephalitis in 7 cases. Without appropriate antiviral therapy, recovery was uneventful in all but 1 patient, who had neurologic sequelae of quadriplegia and developmental delay.
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