[Nicorandil-associated anal ulceration].

Area of Science:

• Cardiology
• Gastroenterology
• Dermatology

Background:

• Nicorandil is a potassium-channel activator used for angina pectoris.
• The first reported cases of nicorandil-induced anal ulcerations emerged in 2002.

Observation:

• A 71-year-old male patient experienced a two-year history of anal ulcerations.
• These ulcerations emerged within months of starting nicorandil treatment.
• Histological examination revealed granulation tissue with non-specific chronic inflammation.

Findings:

• Nicorandil treatment cessation resulted in complete ulcer healing within three months.
• The study highlights a rare but significant side effect of nicorandil therapy.
• Patients often receive high dosages of nicorandil when these ulcerations occur.

Implications:

• Nicorandil can induce chronic and extensive anal ulcerations.
• The exact pathogenesis of these ulcerations remains unknown.
• Dermatologists must be aware of this adverse effect, as drug withdrawal facilitates healing.