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Published on: August 8, 2014
Amlodipine-induced gingival hyperplasia
Ardeshir Lafzi1, Ramin Mostofi Zadeh Farahani, Mohammad Ali Mohajjel Shoja
1Department of Periodontics, School of dentistry, Tabriz University of Medical Sciences, Tabriz, East Azarbaijan, Iran.
Medicina Oral, Patologia Oral Y Cirugia Bucal
|October 31, 2006
Summary
Amlodipine, a medication for hypertension, rapidly caused gingival hyperplasia in a patient. This case highlights a rare but serious side effect of this common cardiovascular drug.
Area of Science:
- Oral Medicine
- Pharmacology
- Dermatology
Background:
- Drug-induced gingival hyperplasia is a significant clinical concern.
- Amlodipine is a widely prescribed calcium channel blocker for hypertension.
Observation:
- A 45-year-old male patient developed rapid gingival enlargement after two months of amlodipine treatment.
- Clinical examination revealed firm, generalized gingival overgrowth without significant inflammation.
Findings:
- Histological analysis confirmed connective tissue hyperplasia, epithelial acanthosis, and elongated rete ridges.
- The findings were consistent with amlodipine-induced gingival hyperplasia.
Implications:
- This case represents one of the fastest instances of amlodipine-induced gingival hyperplasia reported.
- Understanding the pathogenic mechanisms of this rare side effect is crucial for patient management.
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