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Left ventricular mass in patients with hyperthyroidism

Czesław Marcisz1, Gerard Jonderko, Tomasz Wróblewski

  • 1Department of Internal Medicine in Tychy, School of Health Care, Silesian Medical University, Katowice, Poland.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|October 31, 2006
PubMed

Insights

Hyperthyroidism increases left ventricular mass (LVM) through eccentric remodeling, likely due to volume overload. This cardiac adaptation may not reverse even after achieving euthyroid state.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Hyperthyroidism is associated with complex mechanisms affecting left ventricular mass (LVM).
  • Understanding the impact of hyperthyroidism and its treatment on LVM and hemodynamic workload is crucial.

Purpose of the Study:

  • To investigate the effects of hyperthyroidism and thyreostatic therapy on LVM.
  • To determine the interrelationship between LVM and hemodynamic workload factors in hyperthyroid patients.

Main Methods:

  • Echocardiography was used to assess left ventricular parameters in 51 hyperthyroid patients and 30 controls.
  • Measurements included LVM, stroke volume (SV), cardiac output (CO), and blood pressure before and after thiamazole treatment.

Main Results:

  • Hyperthyroid subjects exhibited increased LVM, thickened ventricular walls, elevated SV, CO, and heart rate (HR), with reduced total peripheral resistance (TPR).
  • LVM positively correlated with SV, CO, systolic blood pressure (SBP), and body mass index (BMI).
  • Treatment did not normalize LVM, which correlated with SBP, SV, and BMI (R=0.64, p<0.001).

Conclusions:

  • Increased LVM in hyperthyroidism is likely due to eccentric remodeling from volume overload and may be irreversible.
  • Elevated LVM appears to be an adaptive response to the increased hemodynamic workload in hyperthyroid patients.
Abstract

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