Related Experiment Video
Updated: Jul 19, 2026
08:13
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Left ventricular mass in patients with hyperthyroidism
Czesław Marcisz1, Gerard Jonderko, Tomasz Wróblewski
1Department of Internal Medicine in Tychy, School of Health Care, Silesian Medical University, Katowice, Poland.
Summary
Hyperthyroidism increases left ventricular mass (LVM) through eccentric remodeling, likely due to volume overload. This cardiac adaptation may not reverse even after achieving euthyroid state.
Area of Science:
- Cardiology
- Endocrinology
- Internal Medicine
Background:
- Hyperthyroidism is associated with complex mechanisms affecting left ventricular mass (LVM).
- Understanding the impact of hyperthyroidism and its treatment on LVM and hemodynamic workload is crucial.
Purpose of the Study:
- To investigate the effects of hyperthyroidism and thyreostatic therapy on LVM.
- To determine the interrelationship between LVM and hemodynamic workload factors in hyperthyroid patients.
Main Methods:
- Echocardiography was used to assess left ventricular parameters in 51 hyperthyroid patients and 30 controls.
- Measurements included LVM, stroke volume (SV), cardiac output (CO), and blood pressure before and after thiamazole treatment.
Main Results:
- Hyperthyroid subjects exhibited increased LVM, thickened ventricular walls, elevated SV, CO, and heart rate (HR), with reduced total peripheral resistance (TPR).
- LVM positively correlated with SV, CO, systolic blood pressure (SBP), and body mass index (BMI).
- Treatment did not normalize LVM, which correlated with SBP, SV, and BMI (R=0.64, p<0.001).
Conclusions:
- Increased LVM in hyperthyroidism is likely due to eccentric remodeling from volume overload and may be irreversible.
- Elevated LVM appears to be an adaptive response to the increased hemodynamic workload in hyperthyroid patients.
Related Concept Videos
01:25Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...