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Ventolin to Salamol--a crossover study in New Zealand
1School of Population Health, Auckland University, Auckland. salamol@selectpost.com
Aims:
To assess asthma stability in adults converted from Ventolin to Salamol.
Methods:
Thirty-six general practice adults with documented asthma and using Ventolin at least weekly in the previous 12 months, changed their Ventolin for Salamol for a period of 4 weeks. The validated Asthma Control Questionnaire was applied at the beginning and end of the study period.
Results:
Of the 36 adults, 6/36 (17%; 95%CI 4-29%) prematurely withdrew mainly due to Salamol ineffectiveness. A further 15/36 (42%; 95%CI 25-58%) could not maintain Salamol alone and returned to Ventolin at some time during the study period with 10/15 (67%; 95% CI 42-91%) citing Salamol ineffectiveness. Of the remaining 15/36 who maintained the study design, nearly all had worse asthma stability 14/15 (93%; 95%CI 80-100%).
Conclusions:
Asthma stability was significantly worse with Salamol compared to Ventolin. Psychological features related to changing inhalers, different physical aspects of Salamol inhalers, and pharmacological ineffectiveness are possible explanations.
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