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Risk of stroke in people with type 2 diabetes in the UK: a study using the General Practice Research Database
H E Mulnier1, H E Seaman, V S Raleigh
1Department of Pharmacoepidemiology, Postgraduate Medical School, University of Surrey, Daphne Jackson Road, Manor Park, Guildford, Surrey, UK. h.mulnier@surrey.ac.uk
Diabetologia
|October 31, 2006
Summary
Patients with type 2 diabetes have a significantly higher risk of stroke, especially younger women. This risk decreases with age but is influenced by diabetes duration and other factors.
Area of Science:
- Cardiovascular epidemiology
- Diabetology
- Public health
Background:
- Stroke risk estimates in type 2 diabetes patients vary.
- Understanding these risks is crucial for patient management and public health strategies.
Purpose of the Study:
- To provide reliable risk estimates for stroke in a large UK cohort of type 2 diabetes patients.
- To investigate the association between stroke risk and diabetes, comorbidities, and lifestyle factors.
Main Methods:
- Utilized the General Practice Research Database to identify type 2 diabetes patients (aged 35-89) and matched controls.
- Calculated hazard ratios (HRs) for stroke between 1992 and 1999.
- Examined associations with age, sex, BMI, smoking, hypertension, atrial fibrillation, and diabetes duration.
Main Results:
- The absolute stroke rate was more than double in type 2 diabetes patients (11.91/1000 person-years) compared to controls (5.55/1000 person-years).
- The age-adjusted HR for stroke in type 2 diabetes patients was 2.19 overall, higher in women than men.
- Risk increase was highest in young women (HR 8.18) and decreased with age. Comorbidities/lifestyle were not major contributors.
Conclusions:
- Type 2 diabetes significantly increases stroke risk, with risk decreasing with age and being higher in women.
- Duration of diabetes, smoking, obesity, atrial fibrillation, and hypertension are additional risk factors.
- This study offers robust stroke risk estimates for type 2 diabetes patients in UK general practice.
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