Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simulating focal demyelinating neuropathies: membrane property abnormalities.

D I Stephanova1, A S Alexandrov, A Kossev

  • 1Institute of Biophysics, Bulgarian Academy of Sciences, Acad. G. Bontchev Str., Bl. 21, Sofia 1113, Bulgaria. dsteph@bio.bas.bg

Biological Cybernetics
|October 31, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temperature effects on accommodative processes in simulated amyotrophic lateral sclerosis in the physiological range.

Journal of integrative neuroscience·2017
Same author

Theoretical predication of temperature effects on accommodative processes in simulated amyotrophic lateral sclerosis during hypothermia and hyperthermia.

Journal of integrative neuroscience·2017
Same author

05-01 The Australian SCAP Study: real-world schizophrenia - outcomes and economics.

Acta neuropsychiatrica·2016
Same author

05-02 The Australian SCAP Study: real-world schizophrenia - economics.

Acta neuropsychiatrica·2016
Same author

Theoretical predication of temperature effect on conducting processes in simulated amyotrophic lateral sclerosis at 20-40[Formula: see text]C.

Journal of integrative neuroscience·2016
Same author

[A model of primary open-angle glaucoma: manifestations and outcomes].

Klinicheskaia meditsina·2015

Focal demyelination in nerves, even when severe, may not alter membrane properties enough to be detected by current excitability tests. Mild focal demyelinations are particularly difficult to diagnose using these methods.

Area of Science:

  • Neuroscience
  • Biophysics
  • Clinical Neurology

Background:

  • Membrane potentials and axonal excitability indices are measurable in demyelinating neuropathies.
  • Previous studies investigated uniform demyelination and paranodal demyelination.
  • This study focuses on focal demyelination affecting one to three internodes.

Purpose of the Study:

  • To simulate and analyze membrane property changes in focal demyelination of human motor nerve fibers.
  • To investigate the impact of varying degrees of focal demyelination on axonal excitability.
  • To assess the diagnostic potential of excitability-based approaches for focal demyelinating neuropathies.

Main Methods:

  • Utilized a double-cable model of a human motor nerve fiber with 30 nodes and 29 internodes.

Related Experiment Videos

  • Simulated focal demyelination with 70% (mild) and 96% (severe) myelin reduction in one to three consecutive internodes.
  • Calculated intracellular, extracellular, and electrotonic potentials, along with axonal excitability indices.

    • Main Results:

    • Severe focal demyelination (96% myelin reduction) led to conduction block, while mild demyelination (70%) did not.
    • Simulated membrane property abnormalities in focal demyelination were less pronounced than in uniform demyelination.
    • Excitability changes in mild focal demyelination were subtle and difficult to distinguish from normal values.

    Conclusions:

    • Focal demyelinations are specific indicators of acquired demyelinating neuropathies.
    • Excitability-based diagnostic tools may be limited in detecting mild focal demyelinations.
    • Current diagnostic methods may require refinement to identify subtle changes associated with focal nerve fiber demyelination.