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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

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Transcatheter aortic valve implantation with the Trilogy valve for symptomatic native aortic regurgitation (ALIGN-AR): a pivotal, multicentre, single-arm, investigational device exemption study.

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Related Experiment Video

Updated: Jul 19, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

[Percutaneously implantable aortic valve: the JenaValve concept evolution].

Hans R Figulla1, Markus Ferrari

  • 1Medizinische Klinik I (Kardiologie, Angiologie, Pneumologie, Internistische Intensivmedizin) der Friedrich-Schiller-Universität Jena. Hans.Figulla@med.uni-jena.de

Herz
|October 31, 2006
PubMed
Summary

This study details a novel self-expanding stent-valve system for severe aortic stenosis, offering a minimally invasive alternative to surgery. Developed over 11 years, it reliably anchors within the native aortic valve, requiring further animal testing for clinical validation.

Related Experiment Videos

Last Updated: Jul 19, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Interventional Cardiology

Background:

  • Severe aortic stenosis is increasingly prevalent in elderly and multimorbid patients.
  • Surgical aortic valve replacement poses significant risks for this patient group.
  • Percutaneous aortic valve implantation offers a less invasive alternative.

Purpose of the Study:

  • To describe the development and design of a novel self-expanding stent-valve system.
  • To evaluate the anchoring mechanism and positioning of the stent-valve system.
  • To assess its potential as an alternative to conventional surgical aortic valve replacement.

Main Methods:

  • Development of a self-expanding stent-valve system based on CoreValve principles.
  • Evolution of the system over 11 years, focusing on self-expansion and reduced length.
  • Design of a sophisticated insertion catheter for precise deployment.
  • Planned chronic animal testing for further evaluation.

Main Results:

  • The developed stent-valve system is self-expanding and relatively short.
  • It demonstrates reliable positioning within the native aortic valve cusps.
  • The system effectively anchors the old valve, mimicking physiological forces.
  • The insertion catheter design requires further validation through animal studies.

Conclusions:

  • The novel stent-valve system shows promise for treating severe aortic stenosis in high-risk patients.
  • Its design allows for physiological force transfer and secure anchoring.
  • Further chronic animal testing is essential to establish its safety and efficacy as a surgical alternative.