Search research articles

Search research articles

Related Experiment Videos

Throwing light on DARC.

M Pruenster¹, A Rot

¹Novartis Institutes for BioMedical Research, Brunnerstr. 59, A-1230 Vienna, Austria.

Biochemical Society Transactions

|November 1, 2006

Summary

This summary is machine-generated.

Silent chemokine receptors, like Duffy antigen receptor for chemokines (DARC), regulate leukocyte trafficking. DARC influences chemokine localization and availability, impacting immune cell movement and inflammatory responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy of the entomopathogenic fungus Metarhizium brunneum in controlling the tick Rhipicephalus annulatus under field conditions.

Veterinary parasitology·2014

Same author

The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer.

British journal of cancer·2014

Same author

On-host control of the brown dog tick Rhipicephalus sanguineus Latreille (Acari: Ixodidae) by Metarhizium brunneum (Hypocreales: Clavicipitaceae).

Veterinary parasitology·2012

Same author

The biochemistry and biology of the atypical chemokine receptors.

Immunology letters·2012

Same author

Vitamin D receptor ablation alters skin architecture and homeostasis of dendritic epidermal T cells.

The British journal of dermatology·2005

Same author

Steroid sulfatase in the human hair follicle concentrates in the dermal papilla.

The Journal of investigative dermatology·2002

Same journal

Beyond the scaffold: extracellular matrix uptake in breast cancer.

Biochemical Society transactions·2026

Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026

Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026

Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026

Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026

Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

Chemokines are crucial for directing leukocyte trafficking and immune responses.
Effective regulation of leukocyte recruitment necessitates precise chemokine localization and temporal control.
Silent chemokine receptors, such as Duffy antigen receptor for chemokines (DARC), modulate these processes.

Purpose of the Study:

To investigate the role of DARC in regulating chemokine activity and leukocyte trafficking.
To understand how DARC influences chemokine localization and availability in different compartments.

Main Methods:

Review of experimental evidence on DARC function in endothelial cells and erythrocytes.
Analysis of DARC's involvement in chemokine accumulation, transcytosis, and presentation.

Related Experiment Videos

Examination of DARC's capacity to act as a chemokine sink in the bloodstream.

Main Results:

DARC facilitates the accumulation and presentation of chemokines on endothelial cell surfaces, promoting leukocyte adhesion and emigration.
DARC expressed on erythrocytes sequesters chemokines in the blood, limiting their systemic dissemination.
This sequestration by DARC reduces the impact of chemokines on circulating leukocytes.

Conclusions:

DARC plays a dual role in chemokine regulation, enhancing local recruitment while limiting systemic spread.
DARC's function as a silent receptor is critical for fine-tuning immune cell trafficking and inflammatory processes.
Understanding DARC's mechanisms offers insights into controlling leukocyte-mediated inflammatory diseases.