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Published on: January 7, 2019
The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses
E M Borroni1, C Buracchi, Y Martinez de la Torre
1Istituto Clinico Humanitas, Via Manzoni 56, I-20089 Rozzano, Milan, Italy.
Abstract:
Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokines and targets them to degradation via constitutive ligand-independent internalization. Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and placenta to dampen inflammation in tissues and draining lymph nodes.
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