Related Experiment Video

Updated: Jul 19, 2026

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77
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Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77

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Post-translational control of Nur77

A D Wingate1, J S C Arthur

  • 1MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, UK. a.d.wingate@dundee.ac.uk

Biochemical Society Transactions
|November 1, 2006
PubMed

Insights

Nur77, a nuclear orphan receptor, regulates cell survival and apoptosis. Phosphorylation is a key ligand-independent mechanism controlling Nur77

Area of Science:

  • Molecular biology
  • Cellular signaling

Background:

  • Nur77 is a nuclear orphan receptor involved in cell survival and apoptosis.
  • Cytoplasmic translocation of Nur77 induces cell death, while nuclear retention promotes survival.
  • Nur77 activity is regulated by ligand-independent mechanisms.

Purpose of the Study:

  • To discuss the role of phosphorylation in Nur77 regulation.

Main Methods:

  • Literature review and discussion of existing research on Nur77 phosphorylation.

Main Results:

  • Phosphorylation is identified as a critical mechanism for regulating Nur77's function.
  • Specific phosphorylation events influence Nur77's subcellular localization and downstream effects.

Conclusions:

  • Phosphorylation plays a crucial role in controlling Nur77-mediated cell survival and apoptosis pathways.
  • Understanding Nur77 phosphorylation offers insights into cellular fate determination.

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