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Updated: Jul 19, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Patterns of exposure to glucocorticoid receptor ligand
1University of Bristol, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK. Stafford.Lightman@bristol.ac.uk
Abstract:
Hormones are characteristically secreted in distinct pulses. Corticosterone (in rodents) and cortisol (in human) show profound circadian and ultradian rhythmicity which results in rapid changes in ligand concentration in the circulating blood. The pattern of ultradian glucocorticoid levels shows genetic modulation, can change according to the physiological and pathological status of the animal and can be programmed by neonatal events. Since the tissue response to changes in circulating glucocorticoid levels can be very rapid, changes in ultradian rhythm could allow tissue-specific regulation of glucocorticoid signalling without major changes in mean plasma hormone levels.
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