Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcription factories: structures conserved during differentiation and evolution.

I Faro-Trindade1, P R Cook

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Biochemical Society Transactions
|November 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complex small-world regulatory networks emerge from the 3D organisation of the human genome.

Nature communications·2021
Same author

Nonequilibrium Chromosome Looping via Molecular Slip Links.

Physical review letters·2018
Same author

Extrusion without a motor: a new take on the loop extrusion model of genome organization.

Nucleus (Austin, Tex.)·2018
Same author

Simulating topological domains in human chromosomes with a fitting-free model.

Nucleus (Austin, Tex.)·2016
Same author

Merging drops in a Teflon tube, and transferring fluid between them, illustrated by protein crystallization and drug screening.

Lab on a chip·2015
Same author

A simple model for DNA bridging proteins and bacterial or human genomes: bridging-induced attraction and genome compaction.

Journal of physics. Condensed matter : an Institute of Physics journal·2015

Cellular transcription occurs in specialized factories, concentrating RNA polymerases and factors for efficient gene expression. These transcription factories maintain consistent size and density during cell differentiation.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular functions are compartmentalized, yet transcription compartments are often overlooked in educational materials.
  • Active RNA polymerases and associated proteins form distinct clusters, termed 'factories', within the nucleus.

Purpose of the Study:

  • To review evidence supporting the existence and function of transcription factories.
  • To discuss the implications of gene association with these factories for transcriptional regulation.
  • To examine the structural constancy of transcription factories during cellular differentiation.

Main Methods:

  • Literature review of existing research on RNA polymerases and nuclear organization.
  • Analysis of experimental data regarding the physical properties of transcription factories.

Related Experiment Videos

  • Comparative study of factory characteristics across different cell types and differentiation states.

    • Main Results:

    • Evidence suggests that transcription factories perform most functions necessary for mature RNA transcript generation.
    • Gene association with the correct factory is a prerequisite for transcription.
    • The density and diameter of nucleoplasmic transcription factories remain remarkably constant during cell differentiation, irrespective of polymerase numbers or nuclear volume.

    Conclusions:

    • Transcription factories represent key functional compartments for gene expression.
    • The stable biophysical properties of these factories suggest a fundamental role in maintaining cellular function during differentiation.
    • Further research into transcription factory dynamics can elucidate mechanisms of gene regulation.