Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple chromatin modifications important for gene expression changes in cardiac hypertrophy.

A J Bingham1, L Ooi, I C Wood

  • 1Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK.

Biochemical Society Transactions
|November 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simple method to overcome the inhibitory effect of heparin on DNA amplification.

Cellular oncology (Dordrecht, Netherlands)·2015
Same author

KvSNP: accurately predicting the effect of genetic variants in voltage-gated potassium channels.

Bioinformatics (Oxford, England)·2011
Same author

Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors.

British journal of anaesthesia·2002
Same author

TRPV3 is a temperature-sensitive vanilloid receptor-like protein.

Nature·2002
Same author

Dominant-negative subunits reveal potassium channel families that contribute to M-like potassium currents.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2002
Same author

A longitudinal study of the biometric and refractive changes in full-term infants during the first year of life.

Vision research·2001

Cardiac hypertrophy, an enlargement of heart muscle cells, can lead to heart failure. Researchers identified the transcription factor REST as a key repressor of genes reactivated during this condition.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Gene Regulation

Background:

  • Cardiac hypertrophy involves myocyte growth due to increased heart workload.
  • Excessive cardiac hypertrophy is linked to heart failure.
  • Hypertrophy is characterized by the re-expression of fetal genes.

Purpose of the Study:

  • To elucidate the mechanisms behind fetal gene re-expression in cardiac hypertrophy.
  • To identify key regulatory factors involved in hypertrophic gene expression.

Main Methods:

  • Investigated gene expression changes in cardiac hypertrophy.
  • Focused on the role of transcription factors in regulating hypertrophic genes.

Main Results:

  • Identified the transcription factor REST (repressor element 1-silencing transcription factor) as a crucial repressor.

Related Experiment Videos

  • REST plays a significant role in silencing genes during normal cardiac function that are reactivated in hypertrophy.

    • Conclusions:

    • REST is a key molecular player in preventing the pathological re-expression of fetal genes during cardiac hypertrophy.
    • Understanding REST's function may offer therapeutic targets for heart failure related to hypertrophy.