Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signalling pathways mediating inflammatory responses in brain ischaemia.

A M Planas1, R Gorina, A Chamorro

  • 1IIBB (Institute for Biomedical Research)--CSIC (Spanish Research Council), IDIBAPS (Institute of Biomedical Investigation 'August Pi i Sunyer'), Rosselló 161, planta 6, E-08036 Barcelona, Spain. ampfat@iibb.csic.es

Biochemical Society Transactions
|November 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and neuroanatomical predictors of post-stroke fatigue.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2024
Same author

Optimizing the Definition of Ischemic Core in CT Perfusion: Influence of Infarct Growth and Tissue-Specific Thresholds.

AJNR. American journal of neuroradiology·2022
Same author

Stroke units could be a valid alternative to intensive care units for patients with low-grade aneurysmal subarachnoid haemorrhage.

European journal of neurology·2020
Same author

Rivaroxaban versus aspirin for secondary prevention of ischaemic stroke in patients with cancer: a subgroup analysis of the NAVIGATE ESUS randomized trial.

European journal of neurology·2020
Same author

Leukoaraiosis May Confound the Interpretation of CT Perfusion in Patients Treated with Mechanical Thrombectomy for Acute Ischemic Stroke.

AJNR. American journal of neuroradiology·2019
Same author

Clinical results of infrared coagulation as a treatment of high-grade anal dysplasia: a systematic review.

Techniques in coloproctology·2019

Stroke triggers inflammation and immune suppression. Cytokine signaling pathways, like JAK/STAT, influence cell survival or death, but their complex roles in stroke outcomes require further study.

Area of Science:

  • Neuroscience
  • Immunology
  • Molecular Biology

Background:

  • Stroke induces neuronal damage and inflammation, involving glial cell activation and immune cell infiltration.
  • Cytokines, including pro-inflammatory (e.g., TNFalpha) and anti-inflammatory (e.g., IL-10) types, play critical roles in the ischemic brain.
  • The Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway is central to intracellular cytokine signaling, affecting gene transcription and cellular fate.

Purpose of the Study:

  • To explore the dual role of cytokines in stroke-induced inflammation and cell survival/death.
  • To investigate the involvement of the JAK/STAT pathway and its modulators in stroke.
  • To understand how systemic cytokine changes post-stroke contribute to immune depression and infection risk.

Main Methods:

Related Experiment Videos

  • Review of existing literature on cytokine signaling in stroke.
  • Analysis of the JAK/STAT pathway's role in neuronal survival and death.
  • Examination of systemic immune effects of cytokines following ischemic events.

Main Results:

  • Cytokine effects (pro- or anti-inflammatory) are concentration- and time-dependent, influencing cell survival or death.
  • STAT1 activation is linked to cell death, while STAT3 activation is associated with survival, highlighting the need for JAK/STAT pathway regulation.
  • Stroke can lead to a systemic immunodepression syndrome, increasing susceptibility to infections.

Conclusions:

  • Cytokine actions in stroke are complex, modulated by intracellular signaling pathways like JAK/STAT.
  • Understanding the intricate regulation of JAK/STAT signaling by SOCS, PIAS, and phosphatases is crucial for stroke therapy.
  • Further research is needed to elucidate the specific contributions of cytokines and their signaling pathways to stroke-induced immunodepression and infection risk.