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Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
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Epithelial microchimerism: consistent finding in human liver transplants.

Silvia Gaia1, Susanna Cappia, Antonina Smedile

  • 1Department of Gastroenterology, San Giovanni Battista Hospital, Turin, Italy. silvia.gaia@fastwebnet.it

Journal of Gastroenterology and Hepatology
|November 1, 2006
PubMed
Summary

Male host-derived hepatic cells were identified in female liver grafts after transplantation. These cells, originating from extra-hepatic stem cells, were found to persist long-term within the liver.

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Area of Science:

  • Hepatology
  • Transplantation Immunology
  • Stem Cell Biology

Background:

  • Investigated male host-derived hepatic cells in female liver grafts post-transplant.
  • Examined biopsies from male patients receiving liver transplants from female donors.
  • Assessed grafts with varying degrees of inflammatory damage.

Purpose of the Study:

  • To determine the presence and characteristics of male host-derived hepatic cells in female liver grafts.
  • To evaluate the persistence of these cells over time.
  • To correlate cell presence with graft inflammation.

Main Methods:

  • Utilized immunohistochemistry for cell type differentiation (anticytokeratin antibody).
  • Employed fluorescence in situ hybridization for XY chromosome identification.
  • Analyzed eleven liver biopsies from six male transplant recipients.

Main Results:

  • Host-derived hepatic cells were detected in all but one transplant.
  • Cell frequency ranged from 2.3 to 25 per thousand hepatocytes.
  • These cells persisted for up to 535 days post-transplant, appearing as single cells or small clusters.

Conclusions:

  • Hepatocytes derived from extra-hepatic stem cells are common in human liver grafts.
  • These cells are found in small numbers and persist over extended periods.
  • Suggests a potential role for stem cell-derived hepatocytes in liver regeneration or repair.