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Susceptibility to proteolipid apoprotein and its encephalitogenic determinants in mice
M Endoh1, T Kunishita, J Nihei
1Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan.
International Archives of Allergy and Applied Immunology
|January 1, 1990
Abstract:
We investigated in mice strain differences in induction of experimental allergic encephalomyelitis by proteolipid apoprotein and studied encephalitogenic determinants. SJL/J, C3H/He, CBA/J and A/J mice were high responders, BALB/c and AKR/J mice were moderately susceptible, and DBA/2, B6 and congenic strains of B10 background were low responders. Synthetic peptide 136-150 was encephalitogenic for SJL/J mice, and 215-232 was encephalitogenic for C3H/He mice. These encephalitogenic derterminants are present in the extracellular portion of proteolipid apoprotein in myelin.