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Updated: Jul 19, 2026
Genetic Modification and Recombination of Salivary Gland Organ Cultures
Published on: January 28, 2013
[Coexpression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic
Mo-yi Sun1, Wei Chen, Lian-jia Yang
1Department of Oral and Maxillofacial Surgery, College of Stomatology, The Fourth Military Medical University, Xi'an 710032, China. moyisun@fmmu.edu.cn
Objective:
To observe the expression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic carcinoma (ACC), and to evaluate the relationship of GFAP, alpha-SMA and perineural invasion in ACC.
Methods:
Immunohistochemical SABC method, double-label immunofluorescence and CLSM were used to detect the expression of GFAP and alpha-SMA proteins in salivary ACC tissue samples.
Results:
In salivary ACC tissue samples, both GFAP and alpha-SMA proteins were positive, which were coexpressed in cytoplasm of the same onco-myoepithelial cells.
Conclusions:
There may be Schwann cell differentiation in onco-myoepithelial cell of salivary ACC, and it may be the pathological base of perineural invasion in salivary ACC.
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