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Cholinergic system, rearing environment and trajectory learning during aging in mice.

R Thouvarecq¹, J Caston, P Protais

¹UPRES PSY.CO EA 1780, Faculté des Sciences, Laboratoire de Neurobiologie de l'Apprentissage, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France.

Physiology & Behavior

|November 1, 2006

Summary

Aging impairs spatial memory, but enriched environments may counteract scopolamine effects in mice. Scopolamine hydrobromide reduced learning in mice of all ages, with younger mice showing some benefit from environmental enrichment.

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Area of Science:

Neuroscience
Cognitive Psychology
Animal Behavior

Background:

Aging is associated with cognitive decline, particularly in spatial memory.
Scopolamine hydrobromide is a drug known to induce cognitive deficits.
Environmental enrichment is a potential intervention to mitigate cognitive impairments.

Purpose of the Study:

To investigate the effects of aging and scopolamine hydrobromide on spatial learning and memory in mice.
To determine if environmental enrichment can counteract the cognitive deficits induced by scopolamine hydrobromide in aging mice.

Main Methods:

C57BL6/J mice of three ages (3, 12, and 20 months) were reared in standard or enriched environments.
Mice received subcutaneous injections of scopolamine hydrobromide (0.6 or 1.2 mg/kg) or saline.

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Spatial learning and memory were assessed using a modified Morris water maze, with a fixed starting point.

Main Results:

Spatial learning ability decreased with age in control mice.
Scopolamine hydrobromide impaired spatial learning in mice of all ages compared to controls.
Environmental enrichment antagonized the scopolamine hydrobromide effect in the youngest mice (3 months old).
All mice, regardless of age, treatment, or environment, demonstrated memory retention of the platform location after 7 days.

Conclusions:

Aging negatively impacts spatial learning, and scopolamine hydrobromide exacerbates this effect.
Environmental enrichment shows potential in mitigating scopolamine-induced cognitive impairment, particularly in younger individuals.
Long-term spatial memory appears robust across aging and scopolamine treatment conditions in this model.