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Hemagglutinating activity of Curcuma plants
Polkit Sangvanich1, Sophon Kaeothip, Chantragan Srisomsap
1Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. spolkit@chula.ac.th
Fitoterapia
|November 1, 2006
Summary
Thai medicinal plants from the Curcuma species, specifically Salingalinthong, show strong hemagglutinating activity. These plant extracts demonstrate potential for applications involving red blood cell agglutination.
Area of Science:
- Phytochemistry
- Biochemistry
- Immunology
Background:
- Thai medicinal plants, particularly Curcuma species, are recognized for their diverse bioactive compounds.
- Hemagglutination, the agglutination of red blood cells, is a phenomenon with various biological and diagnostic implications.
Purpose of the Study:
- To investigate the hemagglutinating activity of crude protein extracts from Thai Curcuma species.
- To identify specific Curcuma species exhibiting significant hemagglutination properties.
Main Methods:
- Crude proteins were extracted from Thai Curcuma species using Mg/NP-40.
- Agglutination activity was assessed using rabbit erythrocytes.
- Hemagglutinating activity was quantified to determine the minimal effective concentration.
Main Results:
- Crude protein extracts from several Thai Curcuma species demonstrated hemagglutinating activity against rabbit erythrocytes.
- The extract from Salingalinthong (a Thai Curcuma specie) exhibited the most potent hemagglutinating activity, with a minimum effective concentration of 2 x 10(-5) mg/ml.
Conclusions:
- Thai Curcuma species possess compounds capable of inducing hemagglutination.
- Salingalinthong is a promising source of potent hemagglutinating agents, warranting further investigation for potential applications.
