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Updated: Jul 19, 2026

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
Published on: August 31, 2015
Coccidioides posadasii produces melanin in vitro and during infection
Joshua D Nosanchuk1, Jieh-Juen Yu, Chiung-Yu Hung
1Department of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, Bronx, NY 10461, USA. nosanchu@aecom.yu.edu
Abstract:
Using techniques developed to study melanization in other fungi, we demonstrate that Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or melanin-like compounds in vitro and tissue forms synthesize pigment in vivo. Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis.
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