Related Experiment Video
Updated: Jul 19, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Primary synovial sarcoma
Morris E Hartstein1, Frankie-Lynn Silver, Olivia J Ludwig
1Department of Ophthalmology, Saint Louis University Eye Institute, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA. mhartstein@earthlink.net
Purpose:
To describe the clinicopathologic and immunohistochemical features and treatment of a rare case of primary synovial sarcoma of the orbit.
Design:
Retrospective interventional case report.
Participant:
A 14-year-old young man with histologically proven synovial sarcoma of the orbit. The diagnosis was confirmed by demonstration of a specific chromosomal translocation by polymerase chain reaction studies.
Methods:
The patient was treated with orbital exenteration and followed up for 18 months at regular intervals.
Results:
The tumor was excised completely, and the patient has done well during the initial 1-year follow-up with no sign of recurrence.
Conclusions:
We report the fourth case of synovial sarcoma of the orbit and, at 14 years of age, the youngest patient reported.
Related Concept Videos
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Structural Joints: Synovial Joints
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
