Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visual white matter integrity in schizophrenia.

Pamela D Butler1, Matthew J Hoptman, Jay Nierenberg

  • 1Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd., Orangeburg NY, 10962, USA. butler@nki.rfmh.org

The American Journal of Psychiatry
|November 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential deficits in pattern- versus flash-visual evoked potentials in schizophrenia: relationship to subcortical visual systems, pulvinar nucleus and cognition.

Frontiers in neuroimaging·2026
Same author

Serotonin type 3 receptor (5-HT<sub>3</sub>R) antagonists for negative symptoms and cognitive impairment associated with schizophrenia: a systematic review and meta-analysis.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Opposite sides of different coins: near-diametrical opposition of physiological indices of reduced accuracy of face emotion recognition in schizophrenia and autism spectrum disorders.

Frontiers in neuroimaging·2026
Same author

Baseline Mismatch Negativity Amplitude Predicts Direction and Magnitude of Ketamine Effect in Healthy Volunteers: A Disordinal Effect.

Biological psychiatry·2026
Same author

Virtual Neuronavigation for Parcel-guided TMS.

medRxiv : the preprint server for health sciences·2025
Same author

Effect Size Deflation With Increasing Sample Size in Adjunctive Trials for Negative Symptoms in Schizophrenia: A Meta-Analysis and Meta-Regression Across Mechanisms of Action.

The American journal of psychiatry·2025
Same journal

2026 Annual Meeting: President-Elect Address.

The American journal of psychiatry·2026
Same journal

2026 Annual Meeting: CEO and Medical Director's Address.

The American journal of psychiatry·2026
Same journal

Reports to the Membership.

The American journal of psychiatry·2026
Same journal

Convergent Metabolic Dysregulations But Divergent Contributing Pathways Across Severe Mental Disorders: The Power of Combining Genetics and Metabolomics.

The American journal of psychiatry·2026
Same journal

2026 Annual Meeting: Presidential Address.

The American journal of psychiatry·2026
Same journal

Represcribing Previously Used Antipsychotics: Response to So.

The American journal of psychiatry·2026
See all related articles

Schizophrenia patients exhibit reduced white matter integrity in the optic radiations, suggesting early-stage visual processing deficits. This impacts initial visual input rather than higher-level visual system functions.

Area of Science:

  • Neuroimaging
  • Neuropsychology
  • Psychiatry

Background:

  • Patients with schizophrenia often display visual-processing deficits.
  • The underlying neural mechanisms for these deficits are not fully understood.
  • White matter integrity is crucial for efficient neural signal transmission.

Purpose of the Study:

  • To investigate visual white matter integrity in patients with schizophrenia.
  • To explore the relationship between white matter integrity and visual processing deficits.
  • To determine if deficits are localized to specific visual system pathways.

Main Methods:

  • Diffusion tensor imaging (DTI) was employed to assess white matter integrity.
  • The study included 17 patients diagnosed with schizophrenia and 21 healthy comparison subjects.

Related Experiment Videos

  • White matter integrity was examined in four key visual system regions: optic radiations, striate cortex, inferior parietal lobule, and fusiform gyrus.

    • Main Results:

    • A significant reduction in fractional anisotropy (FA) was observed in the optic radiations of schizophrenia patients compared to controls.
    • No significant differences in FA were found in the striate cortex, inferior parietal lobule, or fusiform gyrus.
    • These results point to localized white matter abnormalities in the early visual pathway.

    Conclusions:

    • Impaired white matter integrity in the optic radiations suggests early-stage visual processing dysfunction in schizophrenia.
    • The findings support the hypothesis that visual deficits in schizophrenia originate in the initial stages of visual information processing.
    • This highlights the importance of the optic radiations in the pathophysiology of visual disturbances associated with schizophrenia.