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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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Related Experiment Video

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A Method for Labeling Vasculature in Embryonic Mice
09:58

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Published on: October 7, 2011

Hedgehog morphogen in cardiovascular disease.

Maarten F Bijlsma1, Maikel P Peppelenbosch, C Arnold Spek

  • 1Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Circulation
|November 1, 2006
PubMed
Summary
This summary is machine-generated.

The Hedgehog (Hh) protein family is crucial for development. This review explores Hh signaling in cardiovascular development and proposes a novel role for low-density lipoprotein (LDL) in Hh transport.

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Last Updated: May 8, 2026

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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cardiovascular Research

Background:

  • The Hedgehog (Hh) protein family plays a fundamental role in embryonic development.
  • Hh signaling pathways regulate cell growth, differentiation, and tissue patterning.
  • Dysregulation of Hh signaling is implicated in various diseases, including cardiovascular conditions.

Purpose of the Study:

  • To review the basic biology and developmental functions of the Hedgehog (Hh) protein family.
  • To detail Hh signaling in cardiovascular development and its role in ischemia.
  • To propose a novel mechanism for Hh transport involving low-density lipoprotein (LDL).

Main Methods:

  • Literature review of existing research on Hedgehog (Hh) signaling.
  • Analysis of gene discovery, nomenclature, and pathway mechanisms.
  • Discussion of recent findings in Hh signaling related to cardiovascular development and ischemia models.

Main Results:

  • The Hedgehog (Hh) protein family is essential for diverse developmental processes.
  • Hh signaling is critical for cardiovascular development and shows promise in ischemia research.
  • A hypothesis is presented for low-density lipoprotein (LDL) mediating mammalian Hh transport.

Conclusions:

  • Hedgehog (Hh) proteins are vital developmental regulators with significant roles in cardiovascular health.
  • Low-density lipoprotein (LDL) may serve as a novel transporter for Hh proteins in mammals.
  • This potential LDL-Hh interaction opens new avenues for understanding and treating cardiovascular diseases.