Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging and arterial structure-function relations.

Joseph L Jr Izzo1, Gary F Mitchell

  • 1State University of New York at Buffalo, Buffalo, N.Y. USA.

Advances in Cardiology
|November 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study.

Physiological reports·2026
Same author

Association of cardiometabolic disease with subclinical cardiac remodeling in men vs women in the Framingham Heart Study.

European journal of preventive cardiology·2026
Same author

Modifiable Correlates With Systemic Thromboxane Generation and Association With Cardiovascular Outcomes: Results From the Framingham Heart Study.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Associations of noninvasive measures of adiposity with aortic stiffness and microvascular function: The Jackson Heart Study.

American journal of preventive cardiology·2026
Same author

Development and Validation of the AI-HeartAge Model in Framingham and UK Biobank.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Association of Sleep Quality With Arterial Stiffness Measures in a Community-Based Sample.

JACC. Advances·2026
Same journal

Conclusion.

Advances in cardiology·2012
Same journal

Challenges in atrial fibrillation.

Advances in cardiology·2012
Same journal

Antiplatelet therapy in stroke prevention.

Advances in cardiology·2012
Same journal

Bleeding and the use of antiplatelet agents in the management of acute coronary syndromes and atrial fibrillation.

Advances in cardiology·2012
Same journal

Stents and antiplatelet therapy.

Advances in cardiology·2012
Same journal

Genetic considerations.

Advances in cardiology·2012
See all related articles

Aging and hypertension alter arterial structure and function, leading to increased pulse pressure (PP). Brachial cuff blood pressure (BP) measurements inadequately reflect these vascular changes, particularly in large arteries and microcirculation.

Area of Science:

  • Cardiovascular physiology
  • Vascular aging
  • Hypertension research

Background:

  • Aging and hypertension are linked to significant arterial structure and function alterations.
  • Systolic blood pressure (BP) varies across the arterial tree due to pressure wave dynamics.
  • Standard brachial cuff BP measurements fail to capture these complex arterial changes.

Purpose of the Study:

  • To investigate the impact of aging and hypertension on arterial structure and function.
  • To elucidate the mechanisms behind increased pulse pressure (PP) with age.
  • To highlight the limitations of brachial cuff BP in reflecting true arterial hemodynamics.

Main Methods:

  • Analysis of arterial structure and function changes with age and hypertension.

Related Experiment Videos

  • Examination of pressure wave propagation and reflection dynamics.
  • Assessment of vascular wall composition (collagen, elastin, vascular smooth muscle).

    • Main Results:

    • Increased arterial stiffness and dilation in large arteries after middle age.
    • Preserved functional characteristics in intermediate conduit arteries despite dilation.
    • Vasoconstriction, vascular smooth muscle hypertrophy, and rarefaction in the microcirculation.

    Conclusions:

    • Aging and hypertension induce complex arterial remodeling, affecting both large vessels and microcirculation.
    • Increased PP is a consequence of arterial stiffening and altered diameter, not fully captured by cuff BP.
    • Understanding these vascular changes is crucial for managing hypertension in aging populations.