Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimation of skin sodium content via <sup>23</sup>Na magnetic resonance imaging at 3 T using a single-loop surface transmit/receive coil.

Magma (New York, N.Y.)·2026
Same author

Central Systolic Blood Pressure and Left Ventricular Mass: Findings From the International 24-Hour Aortic Blood Pressure Consortium.

Journal of the American Heart Association·2026
Same author

Echocardiographic assessment in arterial hypertension: a contemporary narrative review.

Echo research and practice·2026
Same author

Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Gene Polymorphisms Predict Arterial Stiffness and Serum MGP Levels in Chronic Kidney Disease Patients.

Genes·2025
Same author

Ethnic differences in plasma aldosterone concentration and regulatory mechanisms of aldosterone: protocol for a systematic review and meta-analysis.

BMJ open·2025
Same author

Phenotypes of Hypertension: Impact of Age and Sex on Hemodynamic Mechanisms.

Journal of the American Heart Association·2025

Related Experiment Video

Updated: Jul 19, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Cholesterol, lipids and arterial stiffness.

Ian Wilkinson1, John R Cockcroft

  • 1Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

Advances in Cardiology
|November 1, 2006
PubMed
Summary

High cholesterol is linked to stiffer arteries and higher pulse pressure, increasing cardiovascular risk. Lipid-lowering therapies can reduce arterial stiffness, highlighting it as a modifiable risk factor.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Vascular Physiology

Background:

  • Arterial stiffness and pulse pressure are key indicators of cardiovascular risk.
  • Hypercholesterolaemia is associated with increased central pulse pressure and arterial stiffness compared to controls.
  • These hemodynamic alterations may contribute to cardiovascular disease risk in hypercholesterolaemia patients.

Purpose of the Study:

  • To review the evidence linking cholesterol levels to increased large artery stiffness.
  • To explore potential therapeutic interventions for cholesterol-induced arterial stiffening.
  • To elucidate the mechanisms underlying the relationship between lipids and arterial stiffness.

Main Methods:

  • Literature review of studies investigating arterial stiffness in hypercholesterolaemia.

More Related Videos

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Related Experiment Videos

Last Updated: Jul 19, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

  • Analysis of data on the effects of lipid-lowering therapies on arterial stiffness.
  • Examination of proposed pathophysiological mechanisms connecting lipids and vascular elasticity.

    • Main Results:

    • Patients with hypercholesterolaemia exhibit greater arterial stiffness and central pulse pressure.
    • Lipid-lowering treatments, especially statins, have been shown to reduce arterial stiffness.
    • Atherosclerosis, endothelial dysfunction, inflammation, and alterations in arterial wall elasticity are implicated mechanisms.

    Conclusions:

    • Cholesterol significantly contributes to large artery stiffening, a modifiable cardiovascular risk factor.
    • Therapeutic strategies targeting lipid reduction can improve arterial stiffness.
    • Understanding these links is crucial for enhanced cardiovascular risk stratification and management.