Metabolism and mechanism of action of 5-fluorouracil
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1Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, AL 35205.
Pharmacology & Therapeutics
|January 1, 1990
Abstract:
This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA, thymidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5,10-methylene tetrahydrofolate, FUTP.