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Related Concept Videos

Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

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Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics
10:48

Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics

Published on: July 28, 2015

[Liver involvement during visceral leishmaniasis].

Jean-Pierre Gangneux1, Ludovic Donaghy, Pierre Marty

  • 1Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, CHU de Rennes, 2 rue du Pr. Léon Bernard, 35043 Rennes Cedex, France. jean-pierre.gangneux@chu-rennes.fr

Gastroenterologie Clinique Et Biologique
|November 1, 2006
PubMed
Summary

Visceral leishmaniasis, a severe infection, affects the liver in endemic Mediterranean regions. This review details clinical signs and pathophysiology of hepatic involvement in visceral leishmaniasis.

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Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics
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Area of Science:

  • Parasitology and Tropical Medicine
  • Hepatology
  • Infectious Diseases

Context:

  • Visceral leishmaniasis (VL) is a severe parasitic infection caused by Leishmania parasites, endemic in 62 countries.
  • The Mediterranean basin is a hotspot for Leishmania infantum, with significant case reports in Spain, France, Italy, and Portugal.
  • Parasites disseminate to phagocytic cells in the bone marrow, spleen, liver, and lymph nodes during infection.

Purpose:

  • To review the clinical and biological manifestations of hepatic involvement in visceral leishmaniasis.
  • To elucidate the pathophysiology of liver disease in VL through experimental and pathophysiological data.

Summary:

  • This review synthesizes current knowledge on visceral leishmaniasis, focusing on its impact on the liver.
  • It covers clinical presentations, biological markers, and the underlying mechanisms of liver pathology in VL patients.
  • Emphasis is placed on Leishmania infantum in the Mediterranean region.

Impact:

  • Enhances understanding of VL pathogenesis, particularly liver complications.
  • Provides a comprehensive resource for clinicians and researchers managing VL.
  • Contributes to the knowledge base for developing targeted interventions for hepatic leishmaniasis.