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Updated: Jul 19, 2026
09:22
Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
Published on: May 12, 2020
[Serious bacterial keratitis: a retrospective clinical and microbiological study]
J Kerautret1, L Raobela, J Colin
1Service d'Ophtalmologie, Groupe Hospitalier Pellegrin, Bordeaux. julien.kerautret@chu-bordeaux.fr
Journal Francais D'Ophtalmologie
|November 1, 2006
Summary
Bacterial keratitis in contact lens wearers is often caused by Gram-negative bacilli. This study highlights key clinical and microbiological features of serious bacterial keratitis cases.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Context:
- Bacterial keratitis is a severe ocular infection.
- Contact lens wear is a significant risk factor.
- Understanding causative agents and risk factors is crucial for effective treatment.
Purpose:
- To characterize clinical and microbiological features of bacterial keratitis patients.
- To identify common pathogens and associated risk factors.
- To analyze visual outcomes and their correlations.
Summary:
- A retrospective study analyzed 73 hospitalized bacterial keratitis patients over 32 months.
- Contact lens wear was the primary risk factor (50%), often associated with Gram-negative bacilli (59.3%).
- Pseudomonas aeruginosa and coagulase-negative Staphylococcus were the most frequent isolates. Visual outcome correlated with inflammation and initial acuity.
Impact:
- Highlights the dominance of Gram-negative bacilli in contact lens-related bacterial keratitis.
- Provides data for targeted prevention and treatment strategies.
- Informs clinical practice regarding risk factors and visual prognosis.
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