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Modifying drug release and tablet properties of starch acetate tablets by dry powder agglomeration
Riikka Mäki1, Eero Suihko, Susanne Rost
1Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland. riikka.maki@uku.fi
Journal of Pharmaceutical Sciences
|November 1, 2006
Summary
Triboelectrification-induced agglomeration of drugs with starch acetate (SA) offers controlled drug release. Particle size and charge polarity significantly influence agglomeration efficiency for SA matrix tablets.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Controlled drug release is crucial for effective therapeutics.
- Triboelectrification is an underutilized phenomenon for particle modification.
Purpose of the Study:
- To investigate triboelectrification for agglomerating model drugs with starch acetate (SA).
- To evaluate the impact of agglomeration on drug release rates and tablet properties.
Main Methods:
- Model drugs (N-acetyl-D-glucosamine, caffeine, propranolol hydrochloride) were mixed with SA on a stainless steel plate to induce triboelectrification and agglomeration.
- Agglomerates were characterized using SEM and triboelectric measurements.
- Tablets were formulated with varying disintegrant amounts and compressed.
- Dissolution studies were performed on the formulated tablets.
Main Results:
- Opposite charges generated between SA and caffeine/NAG promoted adhesion, while propranolol HCl showed no adhesion due to similar charging.
- Particle size was critical for agglomeration efficiency, overriding charge magnitude (e.g., smaller caffeine particles agglomerated less effectively than larger NAG particles).
- Agglomeration allowed for modification of drug release rates and tensile strength of SA matrix tablets.
Conclusions:
- Triboelectrification-induced agglomeration is a viable method for controlling drug release from SA matrix tablets.
- Both particle size and charge polarity are key factors in successful drug-polymer agglomeration.
- This technique offers a pathway to tailor drug delivery systems.
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