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The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
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Updated: Jul 19, 2026

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

Neural crest contribution to the cardiovascular system.

Christopher B Brown¹, H Scott Baldwin

¹Department of Pediatrics, Vanderbilt University Medical Center, B3301 MCN, Nashville, Tennessee 37232-2495, USA. chris.brown@vanderbilt.edu

Advances in Experimental Medicine and Biology

|November 2, 2006

Summary

Cardiac neural crest cells are vital for cardiovascular development, forming artery structures and providing essential signals. Disruptions in these cells or their signaling can lead to congenital heart defects.

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Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

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Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube

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Area of Science:

Developmental biology
Cardiovascular science
Embryology

Background:

Normal cardiovascular development involves intricate remodeling of the outflow tract and pharyngeal arch arteries.
This remodeling establishes separate pulmonic and systemic circulations, forming major arteries like the aorta and pulmonary trunk.

Purpose of the Study:

To investigate the role of cardiac neural crest cells in cardiovascular development.
To understand how these cells contribute to the formation and function of the great arteries and cardiac innervation.

Main Methods:

Analysis of neural crest cell origins and migration patterns.
Examination of the cellular and signaling contributions of cardiac neural crest cells to great artery development.

Main Results:

Cardiac neural crest cells differentiate into smooth muscle and pericytes in great arteries and form cardiac neurons.
These cells provide crucial signals for pharyngeal apparatus cell layer maintenance and differentiation.
Reciprocal signaling between cardiac neural crest and secondary heart field is essential for conotruncus development.

Conclusions:

Cardiac neural crest cells are indispensable for normal cardiovascular remodeling and septation.
Cardiovascular defects linked to cardiac neural crest cells can arise from intrinsic neural crest defects or signaling pathway disruptions.