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Multifocal visual-evoked potential in unilateral compressive optic neuropathy.
Linda Semela1, E Bo Yang, Thomas R Hedges
1New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, MA 02111, USA.
Compressive optic neuropathy significantly reduces multifocal visual evoked potential (mfVEP) amplitude and increases signal latency. These mfVEP changes correlate with visual field defects, aiding diagnosis.
Area of Science:
- Ophthalmology
- Neuroscience
- Visual electrophysiology
Background:
- Unilateral compressive optic neuropathy can impair visual function.
- Multifocal visual evoked potentials (mfVEPs) assess the integrity of the visual pathway.
Purpose of the Study:
- To investigate the impact of compressive optic neuropathy on mfVEP amplitude and latency.
- To compare mfVEP findings with visual field data.
Main Methods:
- mfVEP recordings and static automated perimetry were performed on six patients with optic nerve meningiomas.
- Monocular and interocular mfVEP amplitude and latency were analyzed and compared to controls.
Main Results:
- mfVEP amplitude changes corresponded with the location and severity of visual field defects.
- Affected eyes showed response delays ranging from 7.6 to 20.7 ms (interocular) and 7.9 to 13.9 ms (monocular).
Conclusions:
- Compressive optic neuropathy demonstrably reduces mfVEP amplitude and prolongs latency.
- The observed latency increases are comparable to optic neuritis but more pronounced than in ischemic optic neuropathy or glaucoma.
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