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Related Concept Videos

Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

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Related Experiment Video

Updated: Jul 19, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Pregnancy outcome after age 50.

Michal J Simchen1, Yoav Yinon, Orit Moran

  • 1Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel. michal.simchen@sheba.health.gov.il

Obstetrics and Gynecology
|November 2, 2006
PubMed
Summary

Pregnancy after age 50, often requiring oocyte donation, carries higher risks for preterm birth, low birth weight infants, diabetes, and hypertension.

Related Experiment Videos

Last Updated: Jul 19, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Area of Science:

  • Reproductive Medicine
  • Maternal-Fetal Medicine
  • Geriatric Obstetrics

Background:

  • Advanced maternal age (AMA) is associated with increased pregnancy risks.
  • Pregnancy in women over 50 represents a growing, yet understudied, demographic.

Purpose of the Study:

  • To evaluate pregnancy complications in women aged 50-64 years.
  • To compare outcomes with younger women (45-49 years) and the general population.

Main Methods:

  • Retrospective cohort study comparing pregnancy outcomes.
  • Data collected from January 1999 to June 2004.
  • Inclusion of 123 women aged 45+ years, with specific analysis of those 50-64 years.

Main Results:

  • Women aged 50-64 years had significantly higher rates of hospitalization (63% vs. 22%).
  • Higher incidence of multifetal pregnancies, diabetes, and hypertension observed.
  • Increased risk of preterm birth and low birth weight infants compared to younger women.

Conclusions:

  • Pregnancy over 50 is linked to elevated risks of preterm birth and low birth weight neonates.
  • Maternal complications include increased likelihood of diabetes mellitus and hypertension.
  • These findings highlight the need for specialized care in advanced maternal age pregnancies.