[The evaluation of bioavailability and pharmacokinetic parameters of a new antimicrobial preparation trichomikocid]

Area of Science:

• Pharmacology and Microbiology
• Drug Delivery Systems
• Gynecological Infections

Background:

• Current antimicrobial treatments are insufficient for normalizing vaginal microflora and regenerating mucosal layers, leading to recurrent infections.
• Limited therapeutic options exist for combined trichomonal and fungal infections.
• Development of novel, natural-origin drugs is crucial for treating urogenital trichomoniasis and mixed infections.

Purpose of the Study:

• To evaluate the biopenetration and pharmacokinetic properties of novel trichomikocid suppositories.
• To compare the efficacy of vaginal and rectal administration routes versus oral administration.

Main Methods:

• In vitro and in vivo studies were conducted to assess drug penetration.
• Biopenetration levels were measured for vaginal, rectal, and oral administration routes.

Main Results:

• Trichomikocid suppositories demonstrated high biopenetration rates: 95% for vaginal and 96% for rectal use.
• Oral administration showed a significantly lower biopenetration rate of 75%.
• A strong correlation was observed between in vivo and in vitro investigation data.

Conclusions:

• Vaginal and rectal administration of trichomikocid suppositories offers superior biopenetration compared to oral routes.
• These findings support the development of suppositories as an effective drug delivery system for urogenital infections.
• The study validates the predictive accuracy of in vitro models for in vivo drug penetration.