Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gastritis II: Pathophysiology

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

Influenza

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Changes in tomographic parameters across different wearing and cessation periods of apical clearance-fitted rigid gas-permeable contact lenses in keratoconus.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026

Same author

Bilingual evaluation of large language models for patient education in refractive surgery.

International journal of ophthalmology·2026

Same author

Glycoprotein B genotypes and clinical features in patients with recurrent cytomegalovirus anterior segment infection.

The British journal of ophthalmology·2026

Same author

Natural History and Progression of Untreated Keratoconus: An Updated Systematic Review and Meta-Analysis.

Current eye research·2026

Same author

Ocular complications and treatment in patients with facial paralysis: a multi-institutional database study in Taiwan.

Japanese journal of ophthalmology·2026

Same author

Intravital Multiphoton Imaging of the Mouse Ocular Surface: From the Central Cornea to the Limbus.

Methods in molecular biology (Clifton, N.J.)·2025

Search research articles

Related Experiment Video

Updated: Jul 19, 2026

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Ulcerative keratitis caused by Haemophilus influenzae.

Kai-Shiang Yang¹, Hsin-Chiung Lin, David H K Ma

¹Department of Ophthalmology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.

|November 2, 2006

Summary

Haemophilus influenzae is a rare cause of corneal ulcers, often linked to predisposing factors. Prompt diagnosis and antibiotic treatment can preserve vision and eye health.

More Related Videos

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

Related Experiment Videos

Last Updated: Jul 19, 2026

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

Area of Science:

Ophthalmology
Infectious Diseases
Microbiology

Background:

Haemophilus influenzae (H. influenzae) is an uncommon pathogen causing corneal ulcers.
Ocular infections require prompt identification and management to prevent vision loss.

Purpose of the Study:

To detail the clinical progression, therapeutic interventions, antibiotic susceptibility, and visual results in patients with ulcerative keratitis attributed to H. influenzae.

Main Methods:

A retrospective review of 10 patients diagnosed with culture-proven H. influenzae-associated corneal ulcers at a tertiary referral center between 1998 and 2003.
Analysis included patient demographics, identified risk factors, antibiotic sensitivity testing, treatment regimens, and final visual acuity outcomes.

Main Results:

The study included 10 patients with a median age of 61 years. Nine patients had predisposing factors, including prior surgeries and herpetic keratitis.
Antibiotic susceptibility testing revealed resistance to ampicillin in 60% of isolates, but all were sensitive to amoxicillin/clavulanic acid, ceftriaxone, and cefuroxime.
All patients responded favorably to medical antibiotic therapy, with final visual acuity ranging from no light perception to 20/30.

Conclusions:

H. influenzae represents a rare but significant cause of microbial keratitis.
Identifying and addressing predisposing conditions is crucial for managing H. influenzae corneal ulcers.
Timely diagnosis and appropriate antibiotic treatment are essential for preserving ocular integrity and visual function.