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Updated: Jul 19, 2026
07:15
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
[Osborn J wave. A new "channel pathology"? A case report]
1Service de cardiologie HIA Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon Armées, France. sebastien.kerebel@wanadoo.fr
Annales De Cardiologie Et D'Angeiologie
|November 3, 2006
Summary
The J wave, an electrocardiogram anomaly observed during hypothermia, signifies altered repolarization. This finding enhances understanding of cardiac electrophysiology and related channelopathies.
Area of Science:
- Cardiology
- Electrophysiology
Background:
- The J wave, or Osborn wave, is an electrocardiogram anomaly.
- It is classically associated with hypothermia but also occurs in normothermic individuals.
Observation:
- The J wave is characterized by a deflection at the J point, representing the terminal QRS segment.
- This results in an elevated J point relative to the baseline, often with a dome-shaped peak.
Findings:
- The J wave arises from a potential difference between the epicardium and endocardium during ventricular repolarization (phases 1 and 2).
- This gradient is linked to the Ito current, a key factor in cardiac ion channelopathies.
Implications:
- Understanding J wave physiopathology deepens insights into cardiac repolarization mechanisms.
- This knowledge is crucial for diagnosing and managing conditions like Brugada syndrome and other channelopathies.
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