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Related Experiment Video

Updated: Jul 19, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Synchronous multifocal osteosarcoma: report of one case.

Ming-Horng Tsai¹, Chao-Ping Yang, Tang-Her Jaing

¹Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan.

Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi

|November 3, 2006

Summary

Synchronous multifocal osteosarcoma (SMOS) is a rare childhood bone cancer with a poor prognosis. This case highlights the aggressive nature of SMOS, even without lung metastasis, leading to rapid disease progression.

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Area of Science:

Oncology
Pediatric Oncology
Skeletal Biology

Background:

Synchronous multifocal osteosarcoma (SMOS) is a rare variant of osteosarcoma characterized by multiple bone lesions at initial presentation.
SMOS typically affects children and adolescents and is often associated with a dismal prognosis, even without pulmonary metastasis.
The origin of SMOS, whether multicentric or metastatic, remains a subject of debate.

Observation:

A case of SMOS in a 10-year-old girl is presented.
The primary tumor was a sclerotic lesion in the right distal femur.
The patient presented without pulmonary metastasis.

Findings:

Despite aggressive multimodal treatment including chemotherapy and limb salvage surgery, the patient experienced rapid disease progression.
The progression involved multiple axial skeletal sites and symmetrical long bone lesions.
Death occurred within one year of diagnosis, with no evidence of pulmonary metastasis prior to death.

Implications:

This case underscores the aggressive behavior and poor prognosis associated with SMOS, even in the absence of pulmonary metastases.
It highlights the challenges in managing SMOS and the need for further research into its pathogenesis and optimal treatment strategies.
Understanding the behavior of SMOS is crucial for improving outcomes in pediatric bone cancer patients.