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Related Experiment Video

Updated: Jul 19, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Detecting bacterial contamination in platelet products.

Elizabeth L Palavecino1, Roslyn A Yomtovian, Michael R Jacobs

  • 1Department of Pathology, Wake Forest University Medical School, Winston-Salem, North Carolina, USA.

Clinical Laboratory
|November 3, 2006
PubMed
Summary

Bacterial contamination in platelet units is a frequent issue, causing transfusion-associated illness and death. New screening methods are being developed and evaluated to improve detection and patient safety.

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Last Updated: Jul 19, 2026

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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Area of Science:

  • Transfusion Medicine
  • Microbiology
  • Clinical Pathology

Background:

  • Bacterial contamination of platelets is a significant cause of transfusion-associated morbidity and mortality.
  • It is the most common infectious complication of transfusion therapy, affecting 1 in 1,000 to 3,000 units.
  • Factors contributing to this problem include detection method limitations and underrecognition of septic reactions.

Purpose of the Study:

  • To review the practical aspects and feasibility of implementing FDA-cleared methods for detecting bacterial contamination in platelet units.
  • To discuss methods under development for real-time use in blood banks.
  • To highlight the need for defining the clinical sensitivity, specificity, and predictive value of these detection methods.

Main Methods:

  • Review of existing literature on bacterial contamination in platelet units.
  • Evaluation of FDA-cleared detection methods for practical implementation.
  • Discussion of emerging technologies for at-issue bacterial detection.

Main Results:

  • New standards from CAP and AABB mandate screening of platelets for bacterial contamination.
  • Various detection methods are being developed, but their clinical performance varies.
  • The sensitivity, specificity, and predictive value of these methods require further definition for routine use.

Conclusions:

  • Bacterial contamination of platelets remains a critical safety concern in transfusion medicine.
  • Implementing effective screening strategies is essential to mitigate transfusion-associated risks.
  • Ongoing development and validation of sensitive detection methods are crucial for improving blood product safety.