Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Two faces of cytochrome c].

Lech Wojtczak1

  • 1Instytut Biologii Doświadczalnej PAN im. Marcelego Nenckiego, Warszawa. l.wojtczak@nencki.gov.pl

Postepy Biochemii
|November 3, 2006
PubMed
Summary
This summary is machine-generated.

Cytochrome c, a vital haemoprotein in cell respiration, also acts as a signaling molecule in programmed cell death (apoptosis). Its evolutionary differences are key markers in biochemical evolution research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Update on Isolation of Functional Mitochondria from Cells for Bioenergetics Studies.

Methods in molecular biology (Clifton, N.J.)·2021
Same author

Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease.

Current medicinal chemistry·2017
Same author

From mitochondrial large amplitude swelling to the permeability transition - a short historic overview.

Postepy biochemii·2017
Same author

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective.

Journal of lipid research·2016
Same author

Isolation of crude mitochondrial fraction from cells.

Methods in molecular biology (Clifton, N.J.)·2014
Same author

[Half century of the concept of "chemiosmotic" energy coupling ,].

Postepy biochemii·2014

Area of Science:

  • Biochemistry
  • Cell Biology
  • Evolutionary Biology

Background:

  • Cytochrome c was discovered by MacMunn (1886) and its role in cellular respiration identified by Keilin (1925).
  • Its established function in the mitochondrial electron transport chain highlights its importance in cellular function.

Discussion:

  • Recent research reveals cytochrome c's novel role as a signaling molecule in programmed cell death (apoptosis).
  • Amino acid variations in cytochrome c serve as valuable markers for studying biochemical evolution.

Key Insights:

  • Cytochrome c possesses dual roles: essential in energy metabolism and as a mediator of apoptosis.
  • Comparative analysis of cytochrome c sequences provides insights into evolutionary relationships.

Outlook:

Related Experiment Videos

  • Further research can elucidate the precise mechanisms of cytochrome c in apoptosis signaling.
  • Exploring cytochrome c's evolutionary trajectory can enhance our understanding of molecular evolution.