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Fluoride: an adjuvant for mucosal and systemic immunity.

J E Butler1, M Satam, J Ekstrand

  • 1Department of Microbiology, University of Iowa, Iowa City 52242.

Immunology Letters
|December 1, 1990
PubMed
Summary
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Fluoride intake enhances the immune system's antibody production, particularly IgG and IgA, by increasing lymphocytes in gut-associated lymphoid tissues. This adjuvant effect has implications for fluoride therapies globally.

Area of Science:

  • Immunology
  • Toxicology
  • Public Health

Background:

  • Fluoride is known for reducing dental caries and is a proliferative agent.
  • The immune-modulating effects of fluoride, especially in relation to antibody production, require further investigation.
  • Understanding fluoride's impact on lymphoid tissues is crucial for public health.

Purpose of the Study:

  • To investigate the adjuvant effect of fluoride on the immune system in rats.
  • To determine how intragastric fluoride influences Peyer's patches and mesenteric lymph nodes.
  • To assess fluoride's impact on antibody production (IgG, IgA) and T-cell populations.

Main Methods:

  • Rats were administered sodium fluoride (NaF) intragastrically.
  • Ovalbumin (OA) was administered in drinking water, and myelin basic protein (MBP) was used for parenteral immunization.

Related Experiment Videos

  • Flow cytometry and serum antibody activity assays were used to analyze immune responses.

    • Main Results:

    • Intragastric fluoride increased Peyer's patch and mesenteric lymph node size and cellularity.
    • Fluoride enhanced IgG and IgA antibody production to ovalbumin and increased surface immunoglobulin expression.
    • Elevated CD4+ T cells and decreased CD8+ T cells were observed in lymphoid tissues.
    • Serum IgG antibody activity to MBP was significantly increased in rats receiving NaF.

    Conclusions:

    • Fluoride acts as a potent adjuvant, enhancing both humoral and cellular immune responses.
    • The observed effects occurred at fluoride concentrations relevant to human therapeutic and accidental exposures.
    • Fluoride's adjuvant properties have significant implications for fluoride therapy and public health worldwide.