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Substrate-directed stereoselectivity in vicinal diamine-catalyzed synthesis of warfarin
Hyunwoo Kim1, Cindy Yen, Philippa Preston
1Department of Chemistry, University of Toronto, 80 St. Geroge Street, Toronto, ON, M5S 3H6 Canada.
Abstract:
[Structure: see text] A new mechanism involving a diimine intermediate is proposed for vicinal diamine-catalyzed synthesis of warfarin. Decreasing the NCCN dihedral angle by varying the diamine results in an increase in the enantioselectivity of warfarin synthesis.
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