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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Malignant lymphomas in the elderly: a single institute experience highlights future directions
László Váróczy1, Alpár Dankó, Zsófia Simon
13rd Department of Medicine, Institute for Internal Medicine, Medical and Health Science Center, University of Debrecen, Móricz Zs. Krt. 22, H-4032 Debrecen, Hungary. laszlo.varoczy@freemail.hu
Archives of Gerontology and Geriatrics
|November 3, 2006
Summary
Elderly patients with malignant lymphoma experience delayed diagnosis and more advanced stages. Appropriate therapies, including supportive care, significantly improve remission and survival rates in older adults.
Area of Science:
- Oncology
- Geriatric Medicine
- Hematology
Background:
- Malignant lymphomas affect elderly patients disproportionately.
- Older adults often present with delayed diagnosis and advanced disease stages.
Purpose of the Study:
- To analyze the diagnostics and treatment outcomes of elderly malignant lymphoma patients.
- To compare treatment approaches and survival rates between elderly and younger patient cohorts.
Main Methods:
- Retrospective analysis of 181 non-Hodgkin's lymphoma (NHL) and 46 Hodgkin's lymphoma (HL) patients aged 65+ diagnosed between 1980-2005.
- Comparison of diagnostic timelines, disease characteristics, treatment appropriateness, and outcomes (remission, survival) between elderly and younger patients.
Main Results:
- Elderly patients had significantly longer diagnostic delays (NHL: 7.6 vs. 4.1 months; HL: 11.4 vs. 5.6 months).
- Higher rates of advanced stages, comorbidity, and inappropriate primary therapies were observed in the elderly.
- Lower complete remission rates (NHL: 17.1% vs. 61.1%; HL: 63.0% vs. 79.2%) and worsened remission by dose reductions were noted in older patients.
Conclusions:
- Appropriate curative or palliative therapies, considering less toxic protocols and supportive care, are crucial for improving outcomes in elderly malignant lymphoma patients.
- Optimizing treatment strategies for the elderly can lead to better remission and overall survival rates.
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