Related Experiment Video
Updated: Jul 19, 2026

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
Published on: December 19, 2020
Specificity of the immune response to a modified group B meningococcal polysaccharide conjugate vaccine
Samuel Moore1, Esmé K Farley, Peter C Fusco
1Department of Vaccine Research, BioVeris Corporation, 16020 Industrial Drive, Gaithersburg, MD 20877, USA. smoore@bioveris.com
Abstract:
Antibodies to a modified group B meningococcal polysaccharide vaccine were examined for antigenic and functional specificities. Bactericidal determinants were investigated by using immunoaffinity columns and competitive inhibition of bactericidal activity in an in vitro killing assay. We conclude that nearly all of the vaccine-induced bactericidal activity is specific for the native polysaccharide.
Related Concept Videos
Vaccinations
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Vaccines
Cross-reactivity
Bacterial Meningitis II: Pathophysiology
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

