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Updated: Jul 19, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Insights
Preventing pain in neonates is crucial, especially for premature infants at high risk for neurodevelopmental issues. Proven pain management strategies are underused and should be implemented in all neonatal intensive care units (NICUs).
Area of Science:
- Neonatal care
- Pain management
- Neurodevelopmental outcomes
Background:
- Repeated painful exposures in neonates can lead to adverse neurodevelopmental consequences.
- Premature infants, particularly the smallest and sickest, face the highest risk of pain exposure in the NICU.
- There are significant knowledge gaps in optimal neonatal pain prevention and relief.
Purpose of the Study:
- To emphasize the critical need for pain prevention in neonates.
- To highlight the underutilization of existing, safe pain management therapies.
- To advocate for the implementation of comprehensive pain prevention programs in neonatal care settings.
Main Methods:
- Review of current knowledge on neonatal pain.
- Analysis of the risks associated with painful procedures in the NICU.
- Identification of essential components for an effective pain-prevention program.
Main Results:
- Proven and safe therapies for neonatal pain are underused for routine procedures.
- Neonates at highest risk for neurodevelopmental impairment are also most exposed to pain.
- Effective pain management strategies are available but not consistently applied.
Conclusions:
- All healthcare facilities caring for neonates must implement robust pain-prevention programs.
- Programs should include pain assessment, minimization of painful procedures, and effective pharmacologic/non-pharmacologic therapies.
- Eliminating pain during surgery and major procedures is essential for neonatal well-being.
Abstract:
The prevention of pain in neonates should be the goal of all caregivers, because repeated painful exposures have the potential for deleterious consequences. Neonates at greatest risk of neurodevelopmental impairment as a result of preterm birth (ie, the smallest and sickest) are also those most likely to be exposed to the greatest number of painful stimuli in the NICU. Although there are major gaps in our knowledge regarding the most effective way to prevent and relieve pain in neonates, proven and safe therapies are currently underused for routine minor yet painful procedures. Every health care facility caring for neonates should implement an effective pain-prevention program, which includes strategies for routinely assessing pain, minimizing the number of painful procedures performed, effectively using pharmacologic and nonpharmacologic therapies for the prevention of pain associated with routine minor procedures, and eliminating pain associated with surgery and other major procedures.
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