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Related Experiment Videos

Activity-dependent plasticity in the olfactory intrabulbar map.

Carolyn A Marks1, Kai Cheng, Diana M Cummings

  • 1Developmental Neural Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 3, 2006
PubMed
Summary
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Odorant-induced activity is crucial for refining intrabulbar projections (IBPs) in the olfactory bulb, shaping its internal circuitry. This refinement process in the intrabulbar map continues into adulthood, showing sustained plasticity.

Area of Science:

  • Neuroscience
  • Olfactory system research
  • Sensory map development

Background:

  • Mammalian olfactory bulbs possess two mirror-symmetric glomerular maps.
  • Reciprocal intrabulbar projections (IBPs) link isofunctional glomeruli, forming an intrabulbar map.
  • The development and plasticity of these maps are not fully understood.

Purpose of the Study:

  • To investigate the role of odorant-induced activity in the formation and refinement of intrabulbar projections (IBPs).
  • To determine the developmental timeline and plasticity of the intrabulbar map in mice.

Main Methods:

  • Neural tracers were injected into the glomerular layer of mouse olfactory bulbs.
  • Projection sizes were measured and compared to injection region sizes to assess IBP maturity.

Related Experiment Videos

  • Experiments involved naris occlusion and anosmia to manipulate odorant-induced activity.
  • Developmental stages from 1 to 7 weeks were analyzed.

    • Main Results:

    • Intrabulbar projection (IBP) to injection ratios mature from 5:1 at 1 week to 1:1 by 7 weeks.
    • Odorant-induced activity is not essential for IBP establishment but is critical for their refinement.
    • Activity deprivation affects both developing and mature maps equally, indicating sustained plasticity.

    Conclusions:

    • Odorant-induced activity plays a crucial role in refining the internal circuitry of the olfactory bulb.
    • The intrabulbar map exhibits plasticity into adulthood, without a distinct critical period for refinement.